Evaluation of Modified Date Palm (Phoenix dactylifera L.) Mucilage as a Potential Pharmaceutical Excipient

Investigation on natural sources from plants, animals, and microorganisms that produce gums mucilages goes increasing day by to check their pharmaceutical applications. Different have been studied for effects but the use of date palm (Phoenix dactylifera L.) mucilage as a excipient is still under cover. The aim this study was therefore evaluate compare flow property binding ability crude, purified, modified (hydrolyzed grafted), green synthesized nanoparticles (Zinc oxide (ZnO), cuperic (CuO), silver (Ag), gold (Au)) with hydroxy propyl methyl cellulose (HPMC) commercially available paracetamol tablets. Previously purified (with 58.4% yield) subjected modification (i.e., acidic, basic, enzymatic), grafting (polyacrylamide), synthesis nanoparticles. Flow properties powdered (granular) modified, were compared HPMC tablet granules. Tablets made using granules all types (discussed above), HPMC, tablets weight uniformity, hardness, friability, dissolution rate, disintegration time. When 100 mg/kg sample given mice no oral toxicity found. results obtained during within acceptable ranges in pharmacopeias. pseudoplastic behavior, hygroscopic nature, increased solubility, swelling index across increase temperature, hardness tablets, drug release behavior found better than binders used paracetamol, hence making (crude, modified) an excellent be dosage forms.